After the disappointment of their League Cup final defeat, Chelsea will still fancy their chances of going all the way in the FA Cup this season.
With the Premier League title seemingly out of reach, winning the FA Cup looks to be the Blues last hope of a domestic trophy this term.
While Chelsea will of course be heavy favourites ahead of Wednesday's showdown with Luton Town, Thomas Tuchel's side certainly can't take anything for granted.
The Blues almost crashed out in the fourth round of the FA Cup this season and required extra-time before seeing off Plymouth Argyle at Stamford Bridge back in February.
Chelsea were given quite the scare in that encounter and required a 105th-minute goal from Marcos Alonso to see them progress past an Argyle side who are currently in seventh place in League One.
Town won't be any pushovers at Kenilworth Road, with just one defeat in their last eight games in the Championship.
Welsh boss Nathan Jones has done a sterling job with the Hatters this season and the club currently find themselves well in the mix for the play-offs this term.
Jones' side have nothing to lose, but they might well come up against a Chelsea backlash after their penalty shootout loss to Liverpool in the League Cup final on Sunday.
It was one of the most dramatic goalless draws ever witnessed, with both sides having goals chalked off in a tense 90 minutes and extra-time.
Ultimately it was substitute keeper Kepa Arrizabalaga's penalty that was rocketed over the crossbar which saw Chelsea come away from the national stadium with nothing to show for their efforts.
A midweek game might just be the perfect antidote to put that League Cup final disappointment behind them before Chelsea return to Premier League action at the weekend with a trip to a resurgent Burnley.
The Blues are firm favourites at 4/11 to win in the 90 minutes at Kenilworth Road and are 1/6 to progress safely through to round six.
Meanwhile, Chelsea to go all the way and win the FA Cup for the ninth time in their history is available at 5/1.
Chelsea's loss was, of course, Liverpool's gain and will surely have left the Reds hungry for more Wembley success.
The Reds look the form team at the moment, having won nine in a row before their penalty shootout triumph, with one of those successes coming against Norwich City.
An FA Cup run could provide some respite for the Premier league's bottom side, who actually took the lead when the duo met on 19th February.
However, the Reds roared back to triumph 3-1, with Sadio Mane, Mohamed Salah and new boy Luis Diaz all finding the net.
That trio looks to be Jurgen Klopp's favoured frontline, but their supporting cast is hardly second rate and Diogo Jota will certainly hope to start on Wednesday.
The Portuguese scored when the teams met at Carrow Road in August 2021, a 3-0 win to the Reds, and he is 11/4 to break the deadlock on Wednesday, as he did in Norfolk.
Another man fond of facing the Canaries is Takumi Minamino, who scored a brace either side of a Divock Origi strike in the duo's League Cup meeting in September.
Cup action has been Minamino's consolation this season and he also netted in the fourth-round victory over Cardiff City.
The Japanese is 7/5 to score at anytime and with several youngsters expected to get the nod, Klopp will be looking towards these two to lead the line.
While Dean Smith will be sending his Norwich side out to win at Anfield, the visit of his former club Brentford on Saturday is sure to play a role when he names his side for the game.
The Canaries have kept clean sheets against Charlton and Wolves in this competition, but their run looks set to come to an end, having conceded an average of three goals per game in their last three Premier League outings.
With just one defeat in nine outings since the start of 2022, it has been a positive couple of months for Ralph Hasenhuttl's Southampton.
The Saints are unbeaten in their last six games in all competitions as they prepare to welcome David Moyes' West Ham United to St Mary's on Wednesday.
After back-to-back draws against Leicester City and Newcastle United, the Hammers did manage to get back to winning ways last time out against Wolves.
However, the Irons failed to beat Southampton home or away last season and their last two trips to St Mary's have ended in goalless stalemates.
Hasenhuttl's Saints are unbeaten in their last 11 games on home turf and are 13/10 to win in 90 minutes on Wednesday evening, while they are 4/6 to progress to round six.