Greater Western Sydney have been hit by the news both Phil Davis and Jacob Hopper are facing lengthy spells on the sidelines because of injury.
GWS are priced at 18/1 to win the 2022 AFL grand final but are unlikely to see the duo until the second half of the season as they prepare to undergo surgery.
Davis had been looking in great form after returning from an injury-hit 2021 but unfortunately the curse has struck again.
The influential star damaged his hamstring in the game against Richmond and is looking at up to 12 weeks on the sidelines while he recovers.
Midfielder Hopper is also facing a spell out after being told he needs to undergo a knee operation.
The injuries are another setback for coach Leon Cameron who is already missing Toby Greene through suspension. But he insists they will battle on.
"Unfortunately he's done a really good job on that hamstring," Cameron said. "He goes into surgery and it's probably a 10 or 12-week injury, which is disappointing because he was up and running playing some good footy.
"Two of the guys in our leadership group, an integral part of our team, are going to be out for a long period but we've been there and done it before.
"(Davis) is just a true professional, but there's always going to be a little bit of grieving on injuries for players, especially long-term ones."
There is some better news for the Giants though with Braydon Preuss finally set to make his debut for the club after missing the whole of 2021 through injury.