With just three points separating the two rivals, all eyes will be on Ibrox on Sunday when Rangers host frontrunners Celtic in the Scottish Premiership.
It's expected to be another titanic tussle in Glasgow and here's three head-to-head battles that could go a long way in deciding the potential victors in Govan.
Champions Rangers are now 2/1 to cling to their crown, with Celtic 4/11 to wrestle back domestic supremacy in Ange Postecoglou's maiden season as manager after they missed out on the fabled ten-in-a-row last time around.
Like all games the midfield battle is where so many matches are won and lost. The head-to-head between Scotland teammates Ryan Jack and Callum McGregor looks to be an intriguing one.
Jack has only recently returned to full fitness but did manage to get another 57 minutes of football under his belt in Scotland's 2-2 draw against Austria on Tuesday night.
McGregor, who is still sporting a protective mask since the facial injury he incurred back in January, was named on the bench and did not take part in the friendly in Vienna so he should be fresh for the Old Firm clash at the weekend.
Both Jack and McGregor will be expected to do much of the unseen work on Sunday and win those important 50-50 clashes.
The pair are also capable of popping up with the odd goal, so either one could be the unlikely hero come the weekend.
Rangers are 11/8 to win on home soil on Sunday, with Celtic at 2/1 and the draw 9/4.
At one end of the field it looks set to be a great battle between Rangers defender Connor Goldson and Celtic striker Georgios Giakoumakis.
The Greek forward will be full of confidence after his last performance for the Hoops, in which he scored a hat-trick and provided an assist in a 4-0 demolition job on Ross County at Parkhead.
With eight league goals to his name this season, Giakoumakis looks to be starting to settle into his new surroundings at Celtic following his move last August having scored 26 goals despite his VVV-Venlo being relegated from the Dutch Eredivisie.
Experienced defender Goldson, and the rest of the Rangers backline, look like they will have a job on their hands to try and make sure Giakoumakis, who is 2/1 to score anytime, has a quiet day at the office on Sunday in what will be his first taste of away-day derby action in Glasgow.
At the other end of the field, Rangers boss Giovanni van Bronckhorst will be hoping Alfredo Morelos can come out on top in his battle with Cameron Carter-Vickers.
Morelos' discipline issues have been well documented and undoubtedly there will be some hairy moments concerning the Colombian this weekend.
The forward is expected to overcome a thigh injury in time for the game against Celtic and he will pose a goalscoring threat if he features. Morelos is 9/2 to score the opening goal and 7/5 to score anytime against Celtic.
It will be Carter-Vickers' job to neutralise the Rangers forward, while also keeping a cool head and not being drawn into any shenanigans on the field.
While Celtic ran out comfortable 3-0 winners at Parkhead in their last meeting back in February, Sunday's Old Firm clash is expected to be a much tighter affair.
Expect these six players mentioned to play a big role in the outcome at Ibrox as Scotland's closest title race in many years pens another intriguing chapter.