The Gordon Richards and Damien Moyle-trained Gytrash will jump from barrier two in the Black Caviar Lightning Stakes, the same barrier that saw him win the 2020 renewal at Flemington.
A son of Lope De Vega, the crack six-year-old sprinter caused an upset two years ago when winning the contest as the outsider - with the favourite Nature Strip only managing fourth - and is an 11/1 chance to regain his crown.
That edition of the Lightning was a small, but well-contested race, while the latest renewal is being mooted as one of the best fields ever assembled - the nine runners boasting 12 Group 1s, ten Group 2s and over $37million in prize-money between them.
This year, Gytrash will again tackle old rival Nature Strip and Richards is confident that his gelding can run a big race once more.
"First-up are his best runs by far," Richards told RSN. "I think he likes the straight track and the one where he missed out, he ran third in the Newmarket.
"I would have preferred drawing in the middle of the bunch, but he won this race from this barrier and he's in the race. You can only run against what's around, but I think he'll run well."
As part of his preparation, Gytrash trialled at Gawler last week, finishing second in the 1000-metre heat, with Richards saying he had never been a great track worker, often showing it on race day.
"The times stacked up against the rest of the morning and Ryan (Hurdle) didn't knock him around all that much," Richards added.