Chelsea's poor Premier League run has left them a long way behind Manchester City in the title race but the Blues will expect to get back on track when they host Tottenham.
If you're feeling a sense of deja vu, that'll be because these teams have already met twice in January when the Blues got the better of their London rivals in both legs of their recent EFL Cup semi-final tie.
Spurs looked lacklustre in both ties but particularly in the first leg at Stamford Bridge, where they registered just two shots on target, and their winless run against Chelsea has stretched to a dismal ten matches, eight of which they have lost.
Antonio Conte would love to put an end to that statistic at his old club, and will hope that his players are still high on confidence after Steven Bergwijn's remarkable injury-time double saw them snatch victory from the jaws of defeat against Leicester on Wednesday.
Spurs are unbeaten in nine Premier League matches while their opponents are in the midst of their worst run under Thomas Tuchel, winning just one of their last seven matches in the league, but the visitors have a significant psychological hurdle to overcome at Stamford Bridge.
Heung-Min Son's absence doesn't help a Tottenham attack which generated just five shots on target across the two EFL Cup ties, although Chelsea's previously mean defence has looked far from watertight in the majority of their recent outings.
Conte could turn to Bergwijn in the search for a spark - the Dutchman has made only three Premier League starts this season - but at odds of 4/6 more of the same is expected from Chelsea in a fixture they have dominated. Spurs are 4/1 to end their Bridge hoodoo.
Arsenal's hopes of winning a trophy this season came to an end when they were beaten by Liverpool in the EFL Cup on Thursday and the Gunners must dust themselves off for this meeting with a Burnley side who have caused them problems in recent meetings.
Mikel Arteta's men ran out 1-0 winners at Turf Moor in September but they had failed to win their three previous clashes with the Clarets and another slip-up would harm their bid for a top-four finish - they are currently 2/1 to secure Champions League football.
The Gunners did not have enough players to contest the north London derby a week ago and they will again be without Granit Xhaka while Thomas Partey, back from Afcon but sent off against Liverpool, joins him on their list of suspended midfielders.
With youngsters Albert Sambi Lokonga and Martin Odegaard expected to form the base of Arsenal's midfield, Burnley boss Sean Dyche will aim for this contest to become as physical as possible as he bids to stop a raw but talented Arsenal team.
We've not seen the Clarets in the Premier League since January 2, however, and the sale of Chris Wood leaves them woefully short on firepower and points towards Dyche prioritising defence. Under 2.5 goals could tempt punters at 11/10.
In the match betting, Arsenal are 3/10 while a Burnley victory is priced up at 10/1.
Liverpool have no margin for error in the title race so Jurgen Klopp's Reds can't afford to drop points when they head to south London to take on Crystal Palace with their main attacking weapons Mo Salah and Sadio Mane still at the Africa Cup of Nations.
The visitors have so far shaken off the absence of their superstars, running out comfortable 3-0 winners at home to Brentford last week before defeating Arsenal in the EFL Cup, and they have a fine record in this fixture, winning their last six Premier League games at Selhurst Park and scoring 19 goals in the process.
Palace have looked dangerous under Patrick Vieira but are proving hard for punters to weigh up and their six-match Premier League form figures read an inconsistent WDLWLD. Wilfried Zaha's continued absence hinders the Eagles, although they have scored six goals in three league games without their talisman.
Liverpool were awesome on the road in the earlier part of the season and, while their output in front of goal has fallen, they still put two past Chelsea in a 2-2 draw earlier in the month and did likewise against Arsenal on Thursday.
An interesting contest is expected to go the way of the 11/20 Reds but it's hard to rule out Palace, who can be backed at 19/4.
Leicester had looked on course for three points before disaster struck against Tottenham in midweek and now Brendan Rodgers' forlorn Foxes face another tough examination when Brighton visit the King Power.
Admittedly, Leicester continue to struggle due in no small part to the absence of key players, but that is no excuse for the scale of their capitulation against Spurs and their chances of securing European football are fading fast.
Brighton have similar European aspirations and it's hard not to be impressed by Graham Potter's Seagulls, who were good value for a 1-1 draw with Chelsea in midweek, a result which stretched their unbeaten run to six matches in all competitions.
The lack of a consistent scoring threat continues to hold them back but, if the chances do start to drop, Brighton will consider themselves in with a genuine chance of making more gains on those above them.
The visitors have picked up 15 of their 29 Premier League points on the road and that should worry Leicester. The Foxes are 6/4 while Brighton are 19/10 to extend their fine run.