Three Premier League matches take place this midweek and there are plenty of potential consequences for both the top and bottom of the table.
On Wednesday evening Brighton face Tottenham Hotspur at the Amex Stadium, with the latter keen to get back to winning ways after their late 3-2 loss to Manchester United on Saturday.
Also Liverpool travel to Arsenal in a match which could swing the title race in the Reds' favour, though the Gunners will be stiff opposition as they seek to consolidate fourth place.
Then, on Thursday, there is a massive contest at the bottom of the table as Everton seek to halt their losing run against in-form Newcastle United at Goodison Park.
Jurgen Klopp's Liverpool side travel to Arenal on Wednesday with an extra spring in their step following Manchester City's failure to beat Crystal Palace on Monday evening.
The current league leaders huffed and puffed but simply could not break down a stubborn Eagles defence and left with only a point and are now 4/11 to retain their title.
That means Liverpool (2/1) have the chance to go just one point behind if they can win their game in hand at the Emirates.
The Reds are in the middle of an incredible run of form, having won each of their last eight - emphatically coming through a potentially difficult January without Mo Salah and Sadio Mane due to Africa Cup of Nations duty.
New signing Luis Diaz has been outstanding and Liverpool are certainly looking like the all-conquering side of two years ago.
However, the Gunners will not be an easy game as Mikel Arteta's side are quietly but effectively going about their business.
They have won five in a row and have a one-point advantage over fifth-placed Manchester United - crucially though, they have three games in hand on the Red Devils.
Defensively, they have been much stronger this season than in the past and Arteta is beginning to get an idea of what his best team is.
This will certainly be a tough examination of Liverpool's title credentials and they are 10/11 to win, with the draw at 3/1.
The last few months as far as Tottenham are concerned have been mired by inconsistency - they are capable of brilliance as wins against Manchester City, Leeds, and Everton attest to, but they are also capable of pure mediocrity.
In truth, their performance at Old Trafford was somewhere in the middle, but it still gives rise to the train of thought that Spurs can be flaky, something which may prevent them from qualifying for Europe.
However, there are positives - Harry Kane is getting back to somewhere near his brilliant best, while new signing Dejan Kulusevksi has slotted into the set-up with consummate ease.
A trip to Brighton might be the ideal fixture for them as Graham Potter's side are in the middle of a terrible run of form, losing five in a row and scoring only one goal within that time.
Spurs can be backed at 5/4 and are 11/4 to win by a one-goal margin, with Kane 11/10 to score at anytime.
Everton's match against Newcastle is arguably their biggest for many years, with relegation from the top-flight for the first time in 71 years a genuine prospect.
They have lost eight of their last nine matches, with Lampard's only points as boss coming in their 3-0 win against Leeds United at Goodison last month.
Defensively, they have been torn apart recently, while going forward they have looked pretty insipid.
Lampard still needs to find a formula to get the Toffees back to winning ways and he will be hoping to get another win against Newcastle.
Eddie Howe's side have been in great form, but saw their winning run ended after a narrow 1-0 loss to Chelsea at the weekend.
It is perhaps more of a must-win game for the Toffees and they can be backed 13/10 at to take all three points, with both teams to score 3/4.