Super Bowl fancies the Buffalo Bills could be playing without their star quarterback in Week 10, as they look to bounce back from a shock loss.

The Bills host the Minnesota Vikings in one of the games of the week, while two popular NFC teams face off later before a primetime match-up between two Californian contenders.

Vikings ready to test out Bills

What	Minnesota Vikings @ Buffalo Bills
Where	Highmark Stadium, Orchard Park, New York
When	13:00 ET, Sunday November 13th
How to watch	Fox, streaming via fuboTV
Odds	MIN Vikings +135, BUF Bills -155

It took a win over the Bills last week for the New York Jets to be taken seriously, so maybe it will be the same for the 7-1 Vikings on Sunday.

Minnesota arrive in upstate New York on a six-game winning streak, but still have their doubters because each of those victories were by one score and against teams with deficiencies - or without their starting quarterback in the case of the Miami Dolphins.

And they could catch another break here with Buffalo QB Josh Allen questionable to play because of an elbow injury.

The Bills management could decide it's best to let him heal properly for the crucial closing stretch in which case back-up Case Keenum will be at the controls on Sunday.

He's a game manager type of QB, but one experienced enough to read the Vikings' defense at the line of scrimmage and choose the right checkdown accordingly.

Don't expect many explosive plays from a Keenum-led Bills offense, but anything would be better than last week's second-half effort, in which New York allowed Buffalo only three points and 63 yards after half-time.

Vikings edge rusher Za'Darius Smith could be a key factor too, after Buffalo's pass protection broke down to such an extent last week that Allen was sacked five times and hurt in the attempted throw that could rule him out this week.

Minnesota's record of being involved in close games - and winning them - means taking the visitors to cover the +3.0 point Spread at -115 could be a sound move.

McCarthy makes Packers return

What	Dallas Cowboys @ Green Bay Packers
Where	Lambeau Field, Green Bay, Wisconsin
When	16:25 ET, Sunday November 13th
How to watch	Fox, streaming via fuboTV+
Odds	DAL Cowboys -205, GB Packers +175

Cowboys head coach Mike McCarthy returns to Green Bay to lead a team for the first time since he was released by the Packers after 13 years at the helm.

And he could hardly have hand-picked a better time to be facing his former team as the Packers are reeling from a five-game losing streak that has put their playoff hopes in major jeopardy while Dallas are fully rested coming off a bye week.

To see an Aaron Rodgers-led team look so lacklustre on offense has been a weird sight and injuries have truly hobbled the NFC North champions now.

RB Aaron Jones (foot) returned to practice on Wednesday but many other key players are still likely to be missing, including two key starters on the offensive line (OT David Bakhtiari, OG Elgton Jenkins) and three starters on defense (LB Rashan Gary, LB De'Vonre Campbell, CB Eric Stokes). 

Rodgers himself missed practice with a right thumb injury this week, which ought to be the deciding factor in opposing Green Bay here.

Despite home advantage and the fact the Packers have won eight of the last nine meetings, Green Bay may not be able to cover the +4.0 point Spread at -110.

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Injury-hit Chargers on the road again

What	Los Angeles Chargers @ San Francisco 49ers
Where	Levi's Stadium, Santa Clara
When	20:20 ET, Sunday November 13th
How to watch	NBC, streaming via fuboTV
Odds	LA Chargers +250, SF 49ers -310

A similar scenario awaits the banged-up Chargers in Santa Clara as they face their second consecutive road game against a San Francisco team getting healthy after their bye.

Following a gritty road win over Atlanta last week, the spread moved sharply against Los Angeles to the point where the Chargers are now underdogs by a full touchdown.

That has been due to all the injuries they are dealing with on offense where wide receivers Keenan Allen and Mike Williams both look set to miss this game.

The Chargers can expect San Francisco to run the ball a lot as they have one of the league's lowest-ranked run defenses. That probably means a big dose of Christian McCaffrey, who will now be fully up to speed with the Niners' playbook.

It could end in a blowout with the hosts, who are -110 to cover a -7.0 point Spread, set to take the spoils in this inter-conference clash.